Biomaterial surface energy-driven ligand assembly strongly regulates stem cell mechanosensitivity and fate on very soft substrates

Although mechanisms of cell–material interaction and cellular mechanotransduction are increasingly understood, the mechanical insensitivity of mesenchymal cells to certain soft amorphous biomaterial substrates has remained largely unexplained. We reveal that surface energy-driven supramolecular liga...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Razafiarison, Tojo, Holenstein, Claude N., Stauber, Tino, Jovic, Milan, Vertudes, Edward, Loparic, Marko, Kawecki, Maciej, Bernard, Laetitia, Silvan, Unai, Snedeker, Jess G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2018
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939054/
https://ncbi.nlm.nih.gov/pubmed/29666253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704543115
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