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TrkB-mediated activation of the phosphatidylinositol-3-kinase/Akt cascade reduces the damage inflicted by oxygen-glucose deprivation in area CA3 of the rat hippocampus

The selective vulnerability of hippocampal area CA1 to ischemia-induced injury is a well-known phenomenon. However, the cellular mechanisms that confer resistance to area CA3 against ischemic damage remain elusive. Here, we show that oxygen-glucose deprivation-reperfusion (OGD-RP), an in vitro model...

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Detalhes bibliográficos
Publicado no:Eur J Neurosci
Main Authors: Tecuatl, Carolina, Herrrera-López, Gabriel, Martín-Ávila, Alejandro, Yin, Bocheng, Weber, Stephen, Barrionuevo, Germán, Galván, Emilio J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5938095/
https://ncbi.nlm.nih.gov/pubmed/29480936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ejn.13880
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