Self-renewal and Toll-like receptor Signaling Sustain Exhausted Plasmacytoid Dendritic Cells During Chronic Viral Infection

While characterization of T cell exhaustion has unlocked powerful immunotherapies, the mechanisms sustaining adaptations of short-lived innate cells to chronic inflammatory settings remain unknown. During murine chronic viral infection, we found that concerted events in bone marrow and spleen mediat...

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Publicado en:Immunity
Autores principales: Macal, Monica, Jo, Yeara, Dallari, Simone, Chang, Aaron Y., Dai, Jihong, Swaminathan, Shobha, Wehrens, Ellen, Fitzgerald-Bocarsly, Patricia, Zúñiga, Elina I.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937984/
https://ncbi.nlm.nih.gov/pubmed/29669251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.03.020
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