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Specific Histidine Residues Confer Histatin Peptides with Copper-Dependent Activity against Candida albicans

The histidine-rich salivary peptides of the histatin family are known to bind copper (Cu) and other metal ions in vitro, but the details of these interactions are poorly understood and their implications on in vivo antifungal activity have not been established. Here, we show that availability of Cu...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Conklin, Steven E., Bridgman, Emma C., Su, Qiang, Riggs-Gelasco, Pamela, Haas, Kathryn L., Franz, Katherine J.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937946/
https://ncbi.nlm.nih.gov/pubmed/28763199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00348
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