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pUL34 Binding Near the Human Cytomegalovirus Origin of Lytic Replication Enhances DNA Replication and Viral Growth

The human cytomegalovirus (HCMV) UL34 gene encodes sequence-specific DNA-binding proteins (pUL34) which are required for viral replication. Interactions of pUL34 with DNA binding sites represses transcription of two viral immune evasion genes, US3 and US9. 12 additional predicted pUL34-binding sites...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Slayton, Mark, Hossain, Tanvir, Biegalke, Bonita J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937935/
https://ncbi.nlm.nih.gov/pubmed/29626748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2018.03.017
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