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Genetic evidence that carbohydrate-stimulated insulin secretion leads to obesity

BACKGROUND: A fundamental precept of the carbohydrate-insulin model of obesity is that insulin secretion drives weight gain. However, fasting hyperinsulinemia can also be driven by obesity-induced insulin resistance. We used genetic variation to isolate and estimate the potentially causal effect of...

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Bibliografiske detaljer
Udgivet i:Clin Chem
Main Authors: Astley, Christina M., Todd, Jennifer N., Salem, Rany M., Vedantam, Sailaja, Ebbeling, Cara B., Huang, Paul L., Ludwig, David S., Hirschhorn, Joel N., Florez, Jose C.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937525/
https://ncbi.nlm.nih.gov/pubmed/29295838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1373/clinchem.2017.280727
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