Highly elevated soluble Tim-3 levels correlate with increased hepatocellular carcinoma risk and poor survival of hepatocellular carcinoma patients in chronic hepatitis B virus infection

BACKGROUND AND OBJECTIVE: Upregulated T-cell immunoglobulin and mucin domain containing molecule-3 (Tim-3) in hepatitis B virus (HBV)-specific CD8(+) T-cells contributes to CD8(+) T-cell exhaustion during chronic HBV infection. The membrane-bound Tim-3 can be cleaved from the cell surface by sheddas...

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Bibliografiske detaljer
Udgivet i:Cancer Manag Res
Main Authors: Li, Fang, Li, Na, Sang, Jiao, Fan, Xiude, Deng, Huan, Zhang, Xiaoge, Han, Qunying, Lv, Yi, Liu, Zhengwen
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2018
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937498/
https://ncbi.nlm.nih.gov/pubmed/29760564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S162478
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