Dystrophin's central domain forms a complex filament that becomes disorganized by in-frame deletions

Dystrophin, encoded by the DMD gene, is critical for maintaining plasma membrane integrity during muscle contraction events. Mutations in the DMD gene disrupting the reading frame prevent dystrophin production and result in severe Duchenne muscular dystrophy (DMD); in-frame internal deletions allow...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Delalande, Olivier, Molza, Anne-Elisabeth, Dos Santos Morais, Raphael, Chéron, Angélique, Pollet, Émeline, Raguenes-Nicol, Céline, Tascon, Christophe, Giudice, Emmanuel, Guilbaud, Marine, Nicolas, Aurélie, Bondon, Arnaud, Leturcq, France, Férey, Nicolas, Baaden, Marc, Perez, Javier, Roblin, Pierre, Piétri-Rouxel, France, Hubert, Jean-François, Czjzek, Mirjam, Le Rumeur, Elisabeth
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2018
Ämnen:
Molecular Bases of Disease
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936807/
https://ncbi.nlm.nih.gov/pubmed/29535188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.809798
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