Dystrophin's central domain forms a complex filament that becomes disorganized by in-frame deletions

Dystrophin, encoded by the DMD gene, is critical for maintaining plasma membrane integrity during muscle contraction events. Mutations in the DMD gene disrupting the reading frame prevent dystrophin production and result in severe Duchenne muscular dystrophy (DMD); in-frame internal deletions allow...

Full description

Saved in:
Bibliographic Details
Published in:J Biol Chem
Main Authors: Delalande, Olivier, Molza, Anne-Elisabeth, Dos Santos Morais, Raphael, Chéron, Angélique, Pollet, Émeline, Raguenes-Nicol, Céline, Tascon, Christophe, Giudice, Emmanuel, Guilbaud, Marine, Nicolas, Aurélie, Bondon, Arnaud, Leturcq, France, Férey, Nicolas, Baaden, Marc, Perez, Javier, Roblin, Pierre, Piétri-Rouxel, France, Hubert, Jean-François, Czjzek, Mirjam, Le Rumeur, Elisabeth
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936807/
https://ncbi.nlm.nih.gov/pubmed/29535188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.809798
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items