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Crystallinity of Double-Stranded RNA-Antimicrobial Peptide Complexes Modulates Toll-Like Receptor 3-Mediated Inflammation

Double-stranded RNA (dsRNA) induces production of pro-inflammatory cytokines in normal human epidermal keratinocytes (NHEK) by specific binding to endosomal Toll-like receptor-3 (TLR3). Recently, it has been shown that hyperactivation of TLR3 in psoriatic keratinocytes by dsRNA can occur in the pres...

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Detalhes bibliográficos
Publicado no:ACS Nano
Main Authors: Lee, Ernest Y., Takahashi, Toshiya, Curk, Tine, Dobnikar, Jure, Gallo, Richard L., Wong, Gerard C. L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936640/
https://ncbi.nlm.nih.gov/pubmed/29016111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.7b05234
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