In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model

The urokinase-type plasminogen activator (uPA) loaded hollow nanogels (nUK) were synthesized by a one-step reaction of glycol chitosan and aldehyde capped poly (ethylene oxide). The resultant formulation is sensitive to diagnostic ultrasound (US) of 2 MHz. Herein, we evaluated the in vivo sonothromb...

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Detalhes bibliográficos
Publicado no:Bioact Mater
Main Authors: Teng, Yuming, Jin, Haiqiang, Nan, Ding, Li, Mengnan, Fan, Chenghe, Liu, Yuanyuan, Lv, Pu, Cui, Wei, Sun, Yongan, Hao, Hongjun, Qu, Xiaozhong, Yang, Zhenzhong, Huang, Yining
Formato: Artigo
Idioma:Inglês
Publicado em: KeAi Publishing 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935765/
https://ncbi.nlm.nih.gov/pubmed/29744447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioactmat.2017.08.001
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