All-trans-retinoic acid activates the pro-invasive Src-YAP-Interleukin 6 axis in triple-negative MDA-MB-231 breast cancer cells while cerivastatin reverses this action

All-trans-retinoic acid (RA), the active metabolite of vitamin A, can reduce the malignant phenotype in some types of cancer and paradoxically also can promote cancer growth and invasion in others. For instance, it has been reported that RA induces tumor suppression in tumor xenografts of MDA-MB-468...

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Udgivet i:Sci Rep
Main Authors: Mezquita, Belén, Mezquita, Pau, Pau, Montserrat, Gasa, Laura, Navarro, Lourdes, Samitier, Mireia, Pons, Miquel, Mezquita, Cristóbal
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935706/
https://ncbi.nlm.nih.gov/pubmed/29728589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25526-1
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