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Variable Cell Line Pharmacokinetics Contribute to Non-linear Treatment Response in Heterogeneous Cell Populations
We develop a combined experimental-mathematical framework to investigate heterogeneity in the context of breast cancer treated with doxorubicin. We engineer a cell line to over-express the multi-drug resistance 1 protein (MDR1), an ATP-dependent pump that effluxes intracellular drug. Co-culture expe...
Enregistré dans:
| Publié dans: | Ann Biomed Eng |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5935587/ https://ncbi.nlm.nih.gov/pubmed/29484528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10439-018-2001-2 |
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