The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment

Asymmetrically dividing muscle stem cells in skeletal muscle give rise to committed cells, where the myogenic determination factor Myf5 is transcriptionally activated by Pax7. This activation is dependent on Carm1, which methylates Pax7 on multiple arginine residues, to recruit the ASH2L:MLL1/2:WDR5...

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Udgivet i:Cell Stem Cell
Main Authors: Chang, Natasha C., Sincennes, Marie-Claude, Chevalier, Fabien P., Brun, Caroline E., Lacaria, Melanie, Segalés, Jessica, Muñoz-Cánovez, Pura, Ming, Hong, Rudnicki, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935555/
https://ncbi.nlm.nih.gov/pubmed/29681515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.03.022
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