A carregar...
Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin
PRC2 is a therapeutic target for several types of cancers currently undergoing clinical trials. Its activity is regulated by a positive feedback loop whereby its terminal enzymatic product, H3K27me3, is specifically recognized and bound by an aromatic cage present in its EED subunit. The ensuing all...
Na minha lista:
| Publicado no: | Mol Cell |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5935545/ https://ncbi.nlm.nih.gov/pubmed/29681499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.03.020 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|