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Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin
PRC2 is a therapeutic target for several types of cancers currently undergoing clinical trials. Its activity is regulated by a positive feedback loop whereby its terminal enzymatic product, H3K27me3, is specifically recognized and bound by an aromatic cage present in its EED subunit. The ensuing all...
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| Опубликовано в: : | Mol Cell |
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| Главные авторы: | , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5935545/ https://ncbi.nlm.nih.gov/pubmed/29681499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.03.020 |
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