Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin

PRC2 is a therapeutic target for several types of cancers currently undergoing clinical trials. Its activity is regulated by a positive feedback loop whereby its terminal enzymatic product, H3K27me3, is specifically recognized and bound by an aromatic cage present in its EED subunit. The ensuing all...

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Vydáno v:Mol Cell
Hlavní autoři: Lee, Chul-Hwan, Yu, Jia-Ray, Kumar, Sunil, Jin, Ying, LeRoy, Gary, Bhanu, Natarajan, Kaneko, Syuzo, Garcia, Benjamin A., Hamilton, Andrew D., Reinberg, Danny
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935545/
https://ncbi.nlm.nih.gov/pubmed/29681499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.03.020
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