The effect of spironolactone on calcineurin inhibitor induced nephrotoxicity: a multicenter randomized, double-blind, clinical trial (the SPIREN trial)

BACKGROUND: Calcineurin inhibitor induced nephrotoxicity contributes to late allograft failure in kidney transplant patients. Evidence points towards aldosterone to play a role in the development of fibrosis in multiple organs. Animal studies have indicated a beneficial effect of mineralocorticoid r...

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Библиографические подробности
Опубликовано в: :BMC Nephrol
Главные авторы: Mortensen, Line Aas, Thiesson, Helle C., Tougaard, Birgitte, Egfjord, Martin, Fischer, Anne Sophie Lind, Bistrup, Claus
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
Предметы:
Study Protocol
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934785/
https://ncbi.nlm.nih.gov/pubmed/29724188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12882-018-0885-6
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