Alpha‐synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation

Aggregation of α‐synuclein is a hallmark of Parkinson's disease and dementia with Lewy bodies. We here investigate the relationship between cytosolic Ca(2+) and α‐synuclein aggregation. Analyses of cell lines and primary culture models of α‐synuclein cytopathology reveal an early phase with red...

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Publicado no:EMBO Rep
Main Authors: Betzer, Cristine, Lassen, Louise Berkhoudt, Olsen, Anders, Kofoed, Rikke Hahn, Reimer, Lasse, Gregersen, Emil, Zheng, Jin, Calì, Tito, Gai, Wei‐Ping, Chen, Tong, Moeller, Arne, Brini, Marisa, Fu, Yuhong, Halliday, Glenda, Brudek, Tomasz, Aznar, Susana, Pakkenberg, Bente, Andersen, Jens Peter, Jensen, Poul Henning
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934765/
https://ncbi.nlm.nih.gov/pubmed/29599149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201744617
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