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Outcome pre-specification requires sufficient detail to guard against outcome switching in clinical trials: a case study

BACKGROUND: Pre-specification of outcomes is an important tool to guard against outcome switching in clinical trials. However, if the outcome is not sufficiently clearly defined, then different definitions could be applied and analysed, with only the most favourable result reported. METHODS: In orde...

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Detalhes bibliográficos
Publicado no:Trials
Main Authors: Kahan, Brennan C., Jairath, Vipul
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932799/
https://ncbi.nlm.nih.gov/pubmed/29720248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-018-2654-z
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