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Outcome pre-specification requires sufficient detail to guard against outcome switching in clinical trials: a case study

BACKGROUND: Pre-specification of outcomes is an important tool to guard against outcome switching in clinical trials. However, if the outcome is not sufficiently clearly defined, then different definitions could be applied and analysed, with only the most favourable result reported. METHODS: In orde...

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Podrobná bibliografie
Vydáno v:Trials
Hlavní autoři: Kahan, Brennan C., Jairath, Vipul
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932799/
https://ncbi.nlm.nih.gov/pubmed/29720248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-018-2654-z
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