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Genetic Variants in TAP Are Associated with High-Grade Cervical Neoplasia

PURPOSE: The transporter associated with antigen processing (TAP) is essential in assembling MHC-I proteins. Human papillomavirus (HPV) evades immune recognition by decreasing class I MHC cell surface expression through down-regulation of TAP1 levels. Consistent with heterogeneity in MHC expression...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Einstein, Mark H., Leanza, Suzanne, Chiu, Lydia G., Schlecht, Nicolas F., Goldberg, Gary L., Steinberg, Bettie M., Burk, Robert D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932631/
https://ncbi.nlm.nih.gov/pubmed/19188174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-1207
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