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Sequential regulatory activity prediction across chromosomes with convolutional neural networks

Models for predicting phenotypic outcomes from genotypes have important applications to understanding genomic function and improving human health. Here, we develop a machine-learning system to predict cell-type–specific epigenetic and transcriptional profiles in large mammalian genomes from DNA sequ...

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Bibliographische Detailangaben
Veröffentlicht in:Genome Res
Hauptverfasser: Kelley, David R., Reshef, Yakir A., Bileschi, Maxwell, Belanger, David, McLean, Cory Y., Snoek, Jasper
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932613/
https://ncbi.nlm.nih.gov/pubmed/29588361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.227819.117
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