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The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex
The TMEM127 tumor suppressor gene encodes a transmembrane protein of unknown function mutated in pheochromocytomas and, rarely, in renal cancers. Tumors with inactivating TMEM127 mutations have increased mTORC1 signaling by undefined mechanisms. Here we report that TMEM127 interacts with the lysosom...
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| Publicado no: | Hum Mol Genet |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5932569/ https://ncbi.nlm.nih.gov/pubmed/29547888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy095 |
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