The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex

The TMEM127 tumor suppressor gene encodes a transmembrane protein of unknown function mutated in pheochromocytomas and, rarely, in renal cancers. Tumors with inactivating TMEM127 mutations have increased mTORC1 signaling by undefined mechanisms. Here we report that TMEM127 interacts with the lysosom...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Hum Mol Genet
Hlavní autoři: Deng, Yilun, Qin, Yuejuan, Srikantan, Subramanya, Luo, Anqi, Cheng, Zi-Ming, Flores, Shahida K, Vogel, Kris S, Wang, Exing, Dahia, Patricia L M
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932569/
https://ncbi.nlm.nih.gov/pubmed/29547888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy095
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky