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Highly efficient base editing in Staphylococcus aureus using an engineered CRISPR RNA-guided cytidine deaminase
Novel therapeutic means against Staphylococcus aureus infections are urgently needed due to the emergence of drug-resistant S. aureus. We report the development of a CRISPR RNA-guided cytidine deaminase (pnCasSA–BEC), enabling highly efficient gene inactivation and point mutations in S. aureus. We e...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Chem Sci |
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| Κύριοι συγγραφείς: | , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Royal Society of Chemistry
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5932532/ https://ncbi.nlm.nih.gov/pubmed/29780457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc00637g |
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