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Spatiotemporal Distribution of β-Amyloid in Alzheimer Disease Is the Result of Heterogeneous Regional Carrying Capacities

β-amyloid (Aβ) accumulation in the brain is 1 of 2 pathologic hallmarks of Alzheimer disease (AD), and the spatial distribution of Aβ has been studied extensively ex vivo. Methods: We applied mathematical modeling to Aβ in vivo PET imaging data to investigate competing theories of Aβ spread in AD. R...

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Bibliografiske detaljer
Udgivet i:J Nucl Med
Main Authors: Whittington, Alex, Sharp, David J., Gunn, Roger N.
Format: Artigo
Sprog:Inglês
Udgivet: Society of Nuclear Medicine 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932528/
https://ncbi.nlm.nih.gov/pubmed/29146694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.117.194720
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