Mitochondrial 10398A>G NADH-Dehydrogenase Subunit 3 of Complex I Is Frequently Altered in Intra-Axial Brain Tumors in Malaysia

BACKGROUND: Mitochondria are major cellular sources of reactive oxygen species (ROS) generation which can induce mitochondrial DNA damage and lead to carcinogenesis. The mitochondrial 10398A>G alteration in NADH-dehydrogenase subunit 3 (ND3) can severely impair complex I, a key component of ROS p...

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Detalhes bibliográficos
Publicado no:Brain Tumor Res Treat
Main Authors: Mohamed Yusoff, Abdul Aziz, Zulfakhar, Fatin Najwa, Mohd Khair, Siti Zulaikha Nashwa, Wan Abdullah, Wan Salihah, Abdullah, Jafri Malin, Idris, Zamzuri
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Brain Tumor Society; The Korean Society for Neuro-Oncology; The Korean Society for Pediatric Neuro-Oncology 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932297/
https://ncbi.nlm.nih.gov/pubmed/29717568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14791/btrt.2018.6.e5
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