Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric-flow field-flow fractionation

The heterogeneity of exosomal populations has hindered our understanding of their biogenesis, molecular composition, biodistribution, and functions. By employing asymmetric-flow field-flow fractionation (AF4), we identified two exosome subpopulations (large exosome vesicles, Exo-L, 90-120 nm; small...

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Udgivet i:Nat Cell Biol
Main Authors: Zhang, Haiying, Freitas, Daniela, Kim, Han Sang, Fabijanic, Kristina, Li, Zhong, Chen, Haiyan, Mark, Milica Tesic, Molina, Henrik, Martin, Alberto Benito, Bojmar, Linda, Fang, Justin, Rampersaud, Sham, Hoshino, Ayuko, Matei, Irina, Kenific, Candia M., Nakajima, Miho, Mutvei, Anders Peter, Sansone, Pasquale, Buehring, Weston, Wang, Huajuan, Jimenez, Juan Pablo, Cohen-Gould, Leona, Paknejad, Navid, Brendel, Matthew, Manova-Todorova, Katia, Magalhães, Ana, Ferreira, José Alexandre, Osório, Hugo, Silva, André M., Massey, Ashish, Cubillos-Ruiz, Juan R., Galletti, Giuseppe, Giannakakou, Paraskevi, Cuervo, Ana Maria, Blenis, John, Schwartz, Robert, Brady, Mary Sue, Peinado, Héctor, Bromberg, Jacqueline, Matsui, Hiroshi, Reis, Celso A., Lyden, David
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931706/
https://ncbi.nlm.nih.gov/pubmed/29459780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0040-4
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