Exploiting glycan topography for computational design of Env glycoprotein antigenicity

Mounting evidence suggests that glycans, rather than merely serving as a “shield”, contribute critically to antigenicity of the HIV envelope (Env) glycoprotein, representing critical antigenic determinants for many broadly neutralizing antibodies (bNAbs). While many studies have focused on defining...

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Dettagli Bibliografici
Pubblicato in:PLoS Comput Biol
Autori principali: Yu, Wen-Han, Zhao, Peng, Draghi, Monia, Arevalo, Claudia, Karsten, Christina B., Suscovich, Todd J., Gunn, Bronwyn, Streeck, Hendrik, Brass, Abraham L., Tiemeyer, Michael, Seaman, Michael, Mascola, John R., Wells, Lance, Lauffenburger, Douglas A., Alter, Galit
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931682/
https://ncbi.nlm.nih.gov/pubmed/29677181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006093
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