Mycobactericidal activity of bedaquiline plus rifabutin or rifampin in ex vivo whole blood cultures of healthy volunteers: A randomized controlled trial

BACKGROUND: Bedaquiline, an antimycobacterial agent approved for drug-resistant tuberculosis, is metabolized by CYP3A4, an hepatic enzyme strongly induced by rifampin, an essential part of drug-sensitive tuberculosis treatment. We examined the pharmacokinetic interactions of bedaquiline plus either...

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Publicado en:PLoS One
Main Authors: Wallis, Robert S., Good, Caryn E., O’Riordan, Mary A., Blumer, Jeffrey L., Jacobs, Michael R., Griffiss, J. McLeod, Healan, Amanda, Salata, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931679/
https://ncbi.nlm.nih.gov/pubmed/29718967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0196756
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