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Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy
Autophagy is an intracellular degradation process essential for adaptation to metabolic stress. DAPK2 is a calmodulin-regulated protein kinase, which has been implicated in autophagy regulation, though the mechanism is unclear. Here, we show that the central metabolic sensor, AMPK, phosphorylates DA...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5931534/ https://ncbi.nlm.nih.gov/pubmed/29717115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03907-4 |
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