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Elevated expression of human bHLH factor ATOH7 accelerates cell cycle progression of progenitors and enhances production of avian retinal ganglion cells

The production of vertebrate retinal projection neurons, retinal ganglion cells (RGCs), is regulated by cell-intrinsic determinants and cell-to-cell signaling events. The basic-helix-loop-helix (bHLH) protein Atoh7 is a key neurogenic transcription factor required for RGC development. Here, we inves...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Zhang, Xiang-Mei, Hashimoto, Takao, Tang, Ronald, Yang, Xian-Jie
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931526/
https://ncbi.nlm.nih.gov/pubmed/29717171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25188-z
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