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New opportunities for kinase drug repurposing and target discovery
Protein kinases are major drug targets for oncology. The large size of the kinome, active site conservation and the influence of activation states on drug binding complicates the analysis of their cellular mode of action. In a recent article in Science, Klaeger et al. analysed cellular targets of 24...
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| Publicado no: | Br J Cancer |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5931101/ https://ncbi.nlm.nih.gov/pubmed/29545596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0045-6 |
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