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New opportunities for kinase drug repurposing and target discovery

Protein kinases are major drug targets for oncology. The large size of the kinome, active site conservation and the influence of activation states on drug binding complicates the analysis of their cellular mode of action. In a recent article in Science, Klaeger et al. analysed cellular targets of 24...

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Vydáno v:Br J Cancer
Hlavní autor: Knapp, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931101/
https://ncbi.nlm.nih.gov/pubmed/29545596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0045-6
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