An integrative bioinformatics approach reveals coding and non-coding gene variants associated with gene expression profiles and outcome in breast cancer molecular subtypes

BACKGROUND: Sequence variations in coding and non-coding regions of the genome can affect gene expression and signalling pathways, which in turn may influence disease outcome. METHODS: In this study, we integrated somatic mutations, gene expression and clinical data from 930 breast cancer patients i...

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Veröffentlicht in:Br J Cancer
Hauptverfasser: Győrffy, Balázs, Pongor, Lőrinc, Bottai, Giulia, Li, Xiaotong, Budczies, Jan, Szabó, András, Hatzis, Christos, Pusztai, Lajos, Santarpia, Libero
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931099/
https://ncbi.nlm.nih.gov/pubmed/29559730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0030-0
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