Splicing Factor RBM20 Regulates Transcriptional Network of Titin Associated and Calcium Handling Genes in The Heart

RNA binding motif 20 (RBM20) regulates pre-mRNA splicing of over thirty genes, among which titin is a major target. With RBM20 expression, titin expresses a larger isoform at fetal stage to a smaller isoform at adult resulting from alternative splicing, while, without RBM20, titin expresses exclusiv...

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Bibliografiske detaljer
Udgivet i:Int J Biol Sci
Main Authors: Guo, Wei, Zhu, Chaoqun, Yin, Zhiyong, Wang, Qiurong, Sun, Mingming, Cao, Huojun, Greaser, Marion L.
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5930469/
https://ncbi.nlm.nih.gov/pubmed/29725258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.24117
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