Metabolism of Oxo-Bile Acids and Characterization of Recombinant 12α-Hydroxysteroid Dehydrogenases from Bile Acid 7α-Dehydroxylating Human Gut Bacteria

Bile acids are important cholesterol-derived nutrient signaling hormones, synthesized in the liver, that act as detergents to solubilize dietary lipids. Bile acid 7α-dehydroxylating gut bacteria generate the toxic bile acids deoxycholic acid and lithocholic acid from host bile acids. The ability of...

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Veröffentlicht in:Appl Environ Microbiol
Hauptverfasser: Doden, Heidi, Sallam, Lina A., Devendran, Saravanan, Ly, Lindsey, Doden, Greta, Daniel, Steven L., Alves, João M. P., Ridlon, Jason M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Enzymology and Protein Engineering
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5930368/
https://ncbi.nlm.nih.gov/pubmed/29549099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00235-18
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