Discovery and Biosynthesis of the Antibiotic Bicyclomycin in Distantly Related Bacterial Classes

Bicyclomycin (BCM) is a clinically promising antibiotic that is biosynthesized by Streptomyces cinnamoneus DSM 41675. BCM is structurally characterized by a core cyclo(l-Ile-l-Leu) 2,5-diketopiperazine (DKP) that is extensively oxidized. Here, we identify the BCM biosynthetic gene cluster, which sho...

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Bibliografiske detaljer
Udgivet i:Appl Environ Microbiol
Main Authors: Vior, Natalia M., Lacret, Rodney, Chandra, Govind, Dorai-Raj, Siobhán, Trick, Martin, Truman, Andrew W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Evolutionary and Genomic Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5930311/
https://ncbi.nlm.nih.gov/pubmed/29500259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02828-17
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