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Galectin-9 modulates immunity by promoting Th2/M2 differentiation and impacts survival in patients with metastatic melanoma

PURPOSE: Galectin-9, a β-galactoside binding protein, is defined as a negative regulator of T helper 1 (Th1) immune responses, favoring Th2 bias. Systemic immunity in patients with metastatic melanoma is predominately Th2 biased. We hypothesized galectin-9 could modulate systemic immunity toward Th2...

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Bibliografiske detaljer
Udgivet i:Melanoma Res
Main Authors: Enninga, Elizabeth Ann L., Nevala, Wendy K., Holtan, Shernan G., Leontovich, Alexey A., Markovic, Svetomir N.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5929986/
https://ncbi.nlm.nih.gov/pubmed/27455380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CMR.0000000000000281
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