Over-activation of AKT signaling leading to 5-Fluorouracil resistance in SNU-C5/5-FU cells

Here, we investigated whether over-activation of AKT pathway is important in the resistance to 5-fluorouracil (5-FU) in SNU-C5/5-FU cells, 5-FU-resistant human colon cancer cells. When compared to wild type SNU-C5 cells (WT), SNU-C5/5-FU cells showed over-activation of PI3K/AKT pathway, like increas...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Kim, Eun-Ji, Kang, Gyeoung-Jin, Kang, Jung-Il, Boo, Hye-Jin, Hyun, Jin Won, Koh, Young Sang, Chang, Weon-Young, Kim, Young Ree, Kwon, Jung-Mi, Maeng, Young Hee, Yoo, Eun-Sook, Lee, Chang Hoon, Kang, Hee-Kyoung
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2018
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5929436/
https://ncbi.nlm.nih.gov/pubmed/29731993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24952
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