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Effects of Renal Impairment on Transporter-Mediated Renal Reabsorption of Drugs and Renal Drug-Drug Interactions: A Simulation-Based Study
Renal impairment (RI) significantly impacts the clearance of drugs through changes in glomerular filtration rate, protein binding and alterations in the expression of renal drug transport proteins and hepatic metabolizing enzymes. The objectives of this study were to quantitatively evaluate the effe...
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| Publicado no: | Biopharm Drug Dispos |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5929165/ https://ncbi.nlm.nih.gov/pubmed/29635775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdd.2128 |
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