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Transcriptomics and machine learning predict diagnosis and severity of growth hormone deficiency

BACKGROUND. The effect of gene expression data on diagnosis remains limited. Here, we show how diagnosis and classification of growth hormone deficiency (GHD) can be achieved from a single blood sample using a combination of transcriptomics and random forest analysis. METHODS. Prepubertal treatment-...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Murray, Philip G., Stevens, Adam, De Leonibus, Chiara, Koledova, Ekaterina, Chatelain, Pierre, Clayton, Peter E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928867/
https://ncbi.nlm.nih.gov/pubmed/29618660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93247
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