Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication

[Image: see text] Postmenopausal women are increasingly using botanicals for menopausal symptom relief due to the increased breast cancer risk associated with traditional estrogen therapy. The deleterious effects of estrogens are associated with estrogen receptor (ER)α-dependent proliferation, while...

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Udgivet i:J Nat Prod
Main Authors: Hajirahimkhan, Atieh, Mbachu, Obinna, Simmler, Charlotte, Ellis, Sarah G., Dong, Huali, Nikolic, Dejan, Lankin, David C., van Breemen, Richard B., Chen, Shao-Nong, Pauli, Guido F., Dietz, Birgit M., Bolton, Judy L.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society and American Society of Pharmacognosy 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928484/
https://ncbi.nlm.nih.gov/pubmed/29641206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jnatprod.7b01070
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