Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway

apoE is the primary lipid carrier within the CNS and the strongest genetic risk factor for late onset Alzheimer’s disease (AD). apoE is primarily lipidated via ABCA1, and both are under transcriptional regulation by the nuclear liver X receptor (LXR). Considerable evidence from genetic (using ABCA1...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Fan, Jianjia, Zhao, Rui Qi, Parro, Cameron, Zhao, Wenchen, Chou, Hsien-Ya, Robert, Jerome, Deeb, Tarek Z., Raynoschek, Carina, Barichievy, Samantha, Engkvist, Ola, Maresca, Marcello, Hicks, Ryan, Meuller, Johan, Moss, Stephen J., Brandon, Nicholas J., Wood, Michael W., Kulic, Iva, Wellington, Cheryl L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928439/
https://ncbi.nlm.nih.gov/pubmed/29563219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M081851
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