Common Variation in NLRP3 Is Associated With Early Death and Elevated Inflammasome Biomarkers Among Advanced HIV/TB Co-infected Patients in Botswana

BACKGROUND: Elevated inflammation is associated with early mortality among HIV/tuberculosis (TB) patients starting antiretroviral therapy (ART); however, the sources of immune activation are unclear. We hypothesized that common variation in innate immune genes contributes to excessive inflammation l...

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Veröffentlicht in:Open Forum Infect Dis
Hauptverfasser: Ravimohan, Shruthi, Nfanyana, Kebatshabile, Tamuhla, Neo, Tiemessen, Caroline T, Weissman, Drew, Bisson, Gregory P
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Major Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928406/
https://ncbi.nlm.nih.gov/pubmed/29732382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofy075
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