Interleukin-27 Gene Therapy Prevents the Development of Autoimmune Encephalomyelitis but Fails to Attenuate Established Inflammation due to the Expansion of CD11b(+)Gr-1(+) Myeloid Cells

Interleukin-27 (IL-27) and its subunit P28 (also known as IL-30) have been shown to inhibit autoimmunity and have been suggested as potential immunotherapeutic for autoimmune diseases such as multiple sclerosis (MS). However, the potential of IL-27 and IL-30 as immunotherapeutic, and their mechanism...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Zhu, Jianmin, Liu, Jin-Qing, Liu, Zhihao, Wu, Lisha, Shi, Min, Zhang, Jianchao, Davis, Jonathan P., Bai, Xue-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928207/
https://ncbi.nlm.nih.gov/pubmed/29740452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00873
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