Lamin A/C Maintains Exocrine Pancreas Homeostasis by Regulating Stability of RB and Activity of E2F

Lamins have important roles in nuclear structure and cell signaling. Several diseases are associated with mutations in the lamin A/C gene (LMNA in humans). Patients with familial partial lipodystrophy caused by LMNA mutations develop pancreatitis, but it is not clear how these mutations affect pancr...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Elenbaas, Jared S., Cunha, Juliana Bragazzi, Azuero-Dajud, Rodrigo, Nelson, Bradley, Oral, Elif A., Williams, John A., Stewart, Colin L., Omary, M. Bishr
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927841/
https://ncbi.nlm.nih.gov/pubmed/29366840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2018.01.024
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