A genetic IFN/STAT1/FAS axis determines CD4 T stem cell memory levels and apoptosis in healthy controls and Adult T-cell Leukemia patients

Adult T-cell leukemia (ATL) is an aggressive, chemotherapy-resistant CD4(+)CD25(+) leukemia caused by HTLV-1 infection, which usually develops in a minority of patients several decades after infection. IFN + AZT combination therapy has shown clinical benefit in ATL, although its mechanism of action...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Khouri, Ricardo, Silva-Santos, Gilvanéia, Dierckx, Tim, Menezes, Soraya Maria, Decanine, Daniele, Theys, Kristof, Silva, Aline Clara, Farré, Lourdes, Bittencourt, Achiléa, Mangino, Massimo, Roederer, Mario, Vandamme, Anne-Mieke, Van Weyenbergh, Johan
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2018
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927537/
https://ncbi.nlm.nih.gov/pubmed/29721391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1426423
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