Genetic Polymorphisms of the UDP‐Glucuronosyltransferase 1A7 Gene and Irinotecan Toxicity in Japanese Cancer Patients

Irinotecan often causes unpredictably severe, occasionally fatal, toxicity involving leukopenia or diarrhea. It is converted by carboxyesterase to an active metabolite, SN–38, which is further conjugated and detoxified to SN–38–glucuronide by UDP‐glucuronosyltransferase (UGT). We genotyped the UGT1A...

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Vydáno v:Jpn J Cancer Res
Hlavní autoři: Ando, Maki, Ando, Yuichi, Sekido, Yoshitaka, Ando, Masahiko, Shimokata, Kaoru, Hasegawa, Yoshinori
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2002
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927033/
https://ncbi.nlm.nih.gov/pubmed/12036456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2002.tb01295.x
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