HeLa Cell Transformants Overproducing Mouse Metallothionein Show in vivo Resistance to cis‐Platinum in Nude Mice

Plasmid pSV2MT‐I encoding mouse metallothionein‐I (MT‐I) designed to be expressed under the control of an SV40 promoter was introduced into human HeLa S3 cells. Several transformants (HeLa/MTH) carrying multi‐copies of mouse MT‐I cDNA in their genomes were isolated. These transformants produced 4 to...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Toyoda, Haruka, Mizushima, Tomoe, Satoh, Masahiko, Iizuka, Narushi, Nomoto, Akio, Chiba, Harumi, Mita, Masaharu, Naganuma, Akira, Himeno, Seiichiro, Imura, Nobumasa
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2000
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926218/
https://ncbi.nlm.nih.gov/pubmed/10744049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2000.tb00864.x
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