PTEN/MMAC1 Mutations in Hepatocellular Carcinomas: Somatic Inactivation of Both Alleles in Tumors

Allelic loss of loci on chromosome 10q occurs frequently in hepatocellular carcinomas. Somatic mutations of the PTEN/MMAC1 gene on this chromosome at 10q23 were recently identified in sporadic cancers of the uterus, brain, prostate and breast. To investigate the potential role of PTEN/MMAC1 gene in...

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Détails bibliographiques
Publié dans:Jpn J Cancer Res
Auteurs principaux: Kawamura, Naoki, Nagai, Hisaki, Bando, Koichi, Koyama, Masaaki, Matsumoto, Satoshi, Tajiri, Takashi, Onda, Masahiko, Fujimoto, Jiro, Ueki, Takahiro, Konishi, Noboru, Shiba, Tadayoshi, Emi, Mitsuru
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 1999
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926086/
https://ncbi.nlm.nih.gov/pubmed/10363579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1999.tb00763.x
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