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Concentration of 2′C-methyladenosine triphosphate by Leishmania guyanensis enables specific inhibition of Leishmania RNA virus 1 via its RNA polymerase

Leishmania is a widespread trypanosomatid protozoan parasite causing significant morbidity and mortality in humans. The endobiont dsRNA virus Leishmania RNA virus 1 (LRV1) chronically infects some strains, where it increases parasite numbers and virulence in murine leishmaniasis models, and correlat...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Robinson, John I., Beverley, Stephen M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5925801/
https://ncbi.nlm.nih.gov/pubmed/29511088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001515
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