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Structural mechanism of DNA interstrand cross-link unhooking by the bacterial FAN1 nuclease
DNA interstrand cross-links (ICLs) block the progress of the replication and transcription machineries and can weaken chromosomal stability, resulting in various diseases. FANCD2–FANCI-associated nuclease (FAN1) is a conserved structure-specific nuclease that unhooks DNA ICLs independently of the Fa...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5925792/ https://ncbi.nlm.nih.gov/pubmed/29514982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002171 |
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