Integrating 5hmC and gene expression data to infer regulatory mechanisms

MOTIVATION: Epigenetic mechanisms are known to play a major role in breast cancer. However, the role of 5-hydroxymethylcytosine (5hmC) remains understudied. We hypothesize that 5hmC mediates redox regulation of gene expression in an aggressive subtype known as triple negative breast cancer (TNBC). T...

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Опубликовано в: :Bioinformatics
Главные авторы: Mitrea, Cristina, Wijesinghe, Priyanga, Dyson, Greg, Kruger, Adéle, Ruden, Douglas M, Drăghici, Sorin, Bollig-Fischer, Aliccia
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2018
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Original Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5925763/
https://ncbi.nlm.nih.gov/pubmed/29220513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btx777
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