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Crystal structure and mechanism of human carboxypeptidase O: Insights into its specific activity for acidic residues
Human metallocarboxypeptidase O (hCPO) is a recently discovered digestive enzyme localized to the apical membrane of intestinal epithelial cells. Unlike pancreatic metallocarboxypeptidases, hCPO is glycosylated and produced as an active enzyme with distinctive substrate specificity toward C-terminal...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5924935/ https://ncbi.nlm.nih.gov/pubmed/29636417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803685115 |
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